Pneumococcal Resistance Epidemicity and Virulence

An International Study


Molecular Mechanisms of resistance, virulence and epidemicity in Streptococcus pneumoniae.

Human pathogens face two main kinds of evolutionary challenges:

A. Survival and growth in an antibiotic rich milieu selects for genetic traits of resistance

B. Successful drug resistant strains must also be able to compete with other members of the species for colonization, spread and disease in the host.

The main purpose of this project is to examine the interplay of these two - as well as host and environmental - factors.


January 2006 - New PREVIS related publicationA new article entitled "Identification, prevalence and population structure of non-typeable Streptococcus pneumoniae in carriage samples isolated from preschoolers attending day-care centers" was published in Microbiology.

December 2005 - New PREVIS related publicationA new article entitled "Natural history of drug-resistant clones of Streptococcus pneumoniae colonizing healthy children in Portugal" was published in Microbial Drug Resistant.

November 2005 - New PREVIS related publicationA new article entitled "Assessment of Band-Based Similarity Coefficients for Automatic Type and Subtype Classification of Microbial Isolates Analyzed by Pulsed-Field Gel Electrophoresis" was published in Journal of Clinical Microbiology.

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